Tehran University of Medical Sciences Journal of Food Safety and Hygiene 2476-3241 2 1/2 2017 11 21 42 46 EN Atefeh Araghi Department of Food Hygiene, School of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran Seyed Mohammad Hoseini Department of Pathobiology, School of Veterinary Medicine, Babol Branch, Islamic Azad University, Babol, Iran Reza Sayrafi Department of Pathobiology, School of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran Parisa Sadighara Department of Environmental Health Engineer, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2017 06 07 2017 07 15 Drug residues and its side effects are one of the major problems in global concerning for food contamination. Veterinary drugs in food-producing animals have potential to generate residues in animal-derived products and pose a health hazard to the customers. Sulfadiazine (SDZ) is a group of synthetic antibiotics with broad-spectrum effects. The present study was conducted to assess SDZ hepatotoxicity in chicken embryo models. SDZ was injected on the day 4 of chicken’s incubation. Afterward, the livers and serum samples were collected after hatching. In addition, oxidative stress and biochemical parameters in organs and blood were measured, respectively. We found that there was a significant change in the liver’s enzyme activities. Histopathological findings and liver enzyme activity indicated that SDZ is a hepatotoxic agent. There was a significant increase in lipid peroxidation, and also the same decrease was observed in glutathione level. Furthermore, a small reduction in ferric reducing/antioxidant power and total carotenoids were seen. Overall, the results of this study suggested the presence of oxidative stress in SDZ hepatotoxicity. These data might be useful in applying antioxidant components for protection of hepatotoxicity associated with SDZ therapy. https://jfsh.tums.ac.ir/index.php/jfsh/article/view/75 https://jfsh.tums.ac.ir/index.php/jfsh/article/download/75/40